Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | TSPO | P30536 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246814 | 0.91 | CYP19A1 (0.70) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL2244878 | 0.86 | CYP19A1 (0.60) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL31222301 | 0.86 | CYP19A1 (0.60) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL8154947 | 0.86 | CYP19A1 (0.77) | CYP19A1DNM1P2RX4HDAC6HDAC1 | |
| SCHEMBL29245663 | 0.82 | MAPT (0.51) | CYP19A1TP53MAPTDNM1HDAC6 | |
| SCHEMBL30938111 | 0.82 | MAPT (0.51) | CYP19A1TP53MAPTDNM1HDAC6 | |
| SCHEMBL30574436 | 0.82 | CYP19A1 (0.70) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL22385834 | 0.82 | CYP19A1 (0.70) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL16627135 | 0.82 | PSMD14 (0.51) | CYP19A1TP53MAPTDNM1P2RX4 | |
| SCHEMBL17965657 | 0.82 | MAPT (0.49) | CYP19A1TP53MAPTDNM1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043247-A | A SUBSTITUTED ACRYLIC ACIDS FOR USE IN TREATMENT OF HUMAN AND ANIMAL DISORDERS, AND PURIFICATION OF PROTEINS OR GLYCOPROTEINS, AND TO THEIR USE IN DIAGNOSIS | NOVO NORDISK A/S (DK) | 2000-03-28 | — | — | US | disclosed |
| WO-1997039748-A1 | MODULATORS OF MOLECULES WITH PHOSPHOTYROSINE RECOGNITION UNITS | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | disclosed |