SCHEMBL8174091

SCHEMBL8174091

Cc1c(N)cccc1Oc1cccc(N)c1C

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.62
TSHR P16473 2/20 0.62
PIK3CA P42336 1/20 0.62
ALDH1A1 P00352 6/20 0.50
GAA P10253 2/20 0.47
TDP1 Q9NUW8 3/20 0.46
ADRA2B P18089 1/20 0.46
PTGS1 P23219 1/20 0.46
CD44 P16070 1/20 0.42
KEAP1 Q14145 1/20 0.42
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
DHFR P00374 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13394018 0.98 CYP3A4 (0.59) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL6289998 0.95 CYP3A4 (0.56) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL31179965 0.86 ALDH1A1 (0.58) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL10363801 0.84 CYP3A4 (0.45) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL22830371 0.83 ALDH1A1 (0.50) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL16752103 0.83 CYP3A4 (0.43) CYP3A4TSHRPIK3CAALDH1A1GAA
Hydrochloric Acid SCHEMBL10363807 0.83 ALDH1A1 (0.45) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL265737 0.83 ALDH1A1 (0.62) CYP3A4TSHRPIK3CAALDH1A1GAA
SCHEMBL30258790 0.83 ALDH1A1 (0.62) CYP3A4TSHRPIK3CAALDH1A1GAA
Hydrochloric Acid SCHEMBL312522 0.81 ALDH1A1 (0.60) CYP3A4TSHRPIK3CAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160303522-A1 NANOFILTRATION MEMBRANE AND METHOD OF MANUFACTURING A NANOFILTRATION MEMBRANE EVOQUA WATER TECHNOLOGIES PTE. LTD. (SG) 2016-10-20 US disclosed
WO-2014168584-A1 NANOFILTRATION MEMBRANE AND METHOD OF MANUFACTURING A NANOFILTRATION MEMBRANE NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2014-10-16 WO disclosed
US-6051722-A PRECURSOR FOR POLYIMIDE COPOLYMER; USABLE IN OPTICAL LONG-DISTANCE COMMUNICATION, SIGNAL PROCESSING, PHOTOELECTRIC HYBRID CIRCUITS AND OPTICAL COMPUTERS HITACHI CHEMICAL COMPANY, LTD. (JP) 2000-04-18 US disclosed
US-5550208-A POLYAMIDE PREPARED BY PASSING PRESSURIZED LIQUID PHASE MIXTURE OF DIACID AND DIAMINE THROUGH ORIFICE TO LOW PRESSURE ZONE TO FORM DISPERSION, HEATING AMOCO CORPORATION (US) 1996-08-27 US disclosed
US-5480616-A MEANS FOR PRESSURIZATION, HEATING AND TO DISPERSE REACTANTS IN CONTINUOUS VAPOR PHASE, THROTTLES TO CONTROL PRESURE, FINISHERS TO POST-POLYMERIZE; SHORT RESIDENCE TIME, HANDLES DIFFERENT MELT VISCOSITIES AMOCO CORPORATION (US) 1996-01-02 US disclosed
EP-0123377-B2 Polycondensation process AMOCO CORP (US) 1995-07-12 EP disclosed
US-5264544-A Diamine and armoatic diacid components AMOCO CORPORATION (US) 1993-11-23 US disclosed
US-5081223-A Copolymer with improved glass transition temperature, heat res istance AMOCO CORPORATION (US) 1992-01-14 US disclosed
US-4960549-A EXTRUDING FOAMABLE COMPOSITION INTO CONFINED EXPANSION ZONE, EXPANDING AND COOLING AMOCO CORPORATION (US) 1990-10-02 US disclosed
EP-0376347-A2 Injection moldable blends of poly(etherketones) and polyamide-imides AMOCO CORPORATION (US) 1990-07-04 EP disclosed
US-4358582-A ENGINEERING PLASTICS STANDARD OIL COMPANY (INDIANA) (US) 1982-11-09 US disclosed
US-4358561-A CONTINUOUS PREPARATION FROM ACYLATED AROMATIC DIAMINES AND AROMATIC POLYCARBBOXY COMPOUNDS STANDARD OIL COMPANY (INDIANA) (US) 1982-11-09 US disclosed
US-4348513-A Injection moldable amide-imide copolymers and terpolymers STANDARD OIL COMPANY (INDIANA) (US) 1982-09-07 US disclosed
EP-0043848-A4 Preparation of moulded objects from injection mouldable amide-imide copolymers. STANDARD OIL CO (US) 1982-05-28 EP disclosed
EP-0043848-A1 Preparation of moulded objects from injection mouldable amide-imide copolymers. STANDARD OIL CO (US) 1982-01-20 EP disclosed
WO-1981002014-A1 INJECTION MOLDABLE AMIDE-IMIDE COPOLYMERS STANDARD OIL CO (US) 1981-07-23 WO disclosed
US-4224214-A Injection molding of amic acid and amide-imide polymers and molding compositions STANDARD OIL COMPANY (INDIANA) (US) 1980-09-23 US disclosed
US-4186263-A MOLDABLE AT LOWER TEMPERATURES THAN IN PRIOR ART STANDARD OIL COMPANY (INDIANA) (US) 1980-01-29 US disclosed
US-4167620-A Method for heat treating shaped articles of amide-imide or amic acid polymers STANDARD OIL COMPANY (INDIANA) (US) 1979-09-11 US disclosed
US-4110294-A POLYIMIDES CIBA-GEIGY CORPORATION (US) 1978-08-29 US disclosed