Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 3/20 | 0.34 |
| ▸ | ATP4B | P51164 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800049 | 0.90 | HTR6 (0.39) | HTR6BRD4DRD3HRH3ATP4A | |
| SCHEMBL8168890 | 0.88 | HTR6 (0.40) | HTR6BRD4DRD3HRH3CYP3A4 | |
| SCHEMBL3347328 | 0.86 | HTR6 (0.38) | HTR6BRD4DRD3HRH3ATP4A | |
| SCHEMBL1799069 | 0.86 | HTR6 (0.38) | HTR6BRD4DRD3HRH3ATP4A | |
| SCHEMBL8172357 | 0.86 | HTR6 (0.38) | HTR6BRD4DRD3HRH3ATP4A | |
| SCHEMBL3346600 | 0.86 | HTR6 (0.38) | HTR6BRD4DRD3HRH3ATP4A | |
| SCHEMBL8445677 | 0.86 | HTR6 (0.41) | HTR6 | |
| SCHEMBL1798577 | 0.85 | ACVR1 (0.37) | HTR6BRD4DRD3HRH3 | |
| SCHEMBL8176428 | 0.85 | ACVR1 (0.37) | HTR6BRD4DRD3HRH3 | |
| SCHEMBL1798579 | 0.85 | ACVR1 (0.37) | HTR6BRD4DRD3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| WO-2008095943-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |