SCHEMBL8175437

SCHEMBL8175437

Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)N4CCCNCC4)c3Cl)c2n1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 17/20 0.68
BDKRB2 P30411 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8175435 1.00 RORC (0.68) RORCBDKRB2
SCHEMBL7811056 0.98 RORC (0.70) RORCBDKRB2
SCHEMBL7811053 0.98 RORC (0.70) RORCBDKRB2
Trifluoroacetic Acid SCHEMBL7959588 0.93 RORC (0.73) RORCBDKRB2
SCHEMBL7812560 0.88 RORC (0.72) RORCBDKRB2
SCHEMBL6801276 0.88 RORC (0.69) RORCBDKRB2
SCHEMBL7812552 0.88 RORC (0.72) RORCBDKRB2
SCHEMBL8189075 0.88 RORC (0.68) RORCBDKRB2
SCHEMBL8189078 0.88 RORC (0.68) RORCBDKRB2
SCHEMBL6946090 0.88 RORC (0.83) RORCBDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6071917-A ANALGESICS; ANTIINFLAMMATORY AGENTS; ESPECIALLY FOR THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS; COMPETITIVE BINDING AT RECEPTORS FOURNIER INDUSTRIE ET SANTE (FR) 2000-06-06 US disclosed