Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.48 |
| ▸ | F2 | P00734 | 4/20 | 0.48 |
| ▸ | PLG | P00747 | 4/20 | 0.48 |
| ▸ | KLK1 | P06870 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | PLAT | P00750 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174776 | 0.78 | PLAU (0.44) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL9630060 | 0.74 | HSD17B10 (0.53) | KDM4EGAAALDH1A1TP53CDC25B | |
| SCHEMBL8169486 | 0.70 | PRSS1 (0.39) | PLAUF2PLGPRSS1ALDH1A1 | |
| SCHEMBL8169762 | 0.69 | PRSS1 (0.46) | PLAUF2PRSS1KLKB1BLM | |
| SCHEMBL8170639 | 0.67 | PLAU (0.38) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL8170185 | 0.67 | PLAU (0.38) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL49213 | 0.67 | HSD17B10 (0.74) | KDM4EGAAALDH1A1TP53CDC25B | |
| Ammonia Solution, Strong SCHEMBL11586421 | 0.65 | HSD17B10 (0.71) | KDM4EGAAALDH1A1TP53CDC25B | |
| SCHEMBL8500339 | 0.65 | HSD17B10 (0.71) | KDM4EGAAALDH1A1TP53CDC25B | |
| SCHEMBL1921580 | 0.65 | HSD17B10 (0.71) | KDM4EGAAALDH1A1TP53CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0730590-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |