Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 11/20 | 0.39 |
| ▸ | F2 | P00734 | 6/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 5/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174776 | 0.84 | PLAU (0.44) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8721615 | 0.81 | ALDH1A1 (0.38) | PRSS1F2PRSS2PRSS3ST14 | |
| SCHEMBL8723668 | 0.77 | MAPK10 (0.38) | ALDH1A1 | |
| SCHEMBL8721665 | 0.76 | GAA (0.38) | ALDH1A1 | |
| SCHEMBL8174039 | 0.73 | NQO2 (0.43) | PRSS1PRSS2PRSS3PRMT1ALDH1A1 | |
| SCHEMBL1949948 | 0.71 | PRSS1 (0.41) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8721632 | 0.70 | F2 (0.44) | PRSS1F2PRSS2PRSS3ST14 | |
| SCHEMBL8170185 | 0.70 | PLAU (0.38) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8170639 | 0.70 | PLAU (0.38) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8176115 | 0.70 | PLAU (0.48) | PRSS1F2PLGALDH1A1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| US-5763596-A | PYROLO PYRIMIDINE AND PYRAZOLO PYRIMIDINE COMPOUMDS; TREATMENT OF CARDIOVASCULAR AND BRAIN DISORDERS, ANTIINFLAMMATORY AGENTS | METABASIS THERAPEUTICS, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5674998-A | FOR TREATING CARDIOVASCULAR OR BRAIN DISORDERS, OR AS ANTIINFLAMMATORY AGENT | GENSIA INC. (US) | 1997-10-07 | — | — | US | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0730590-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |