Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8175177 | 0.87 | AAK1 (0.31) | — | |
| SCHEMBL8168553 | 0.87 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8181368 | 0.81 | RAB9A (0.36) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL7108664 | 0.79 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL7108665 | 0.79 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL7092947 | 0.78 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8175083 | 0.78 | RARB (0.35) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL7914492 | 0.78 | MAPT (0.35) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9424956 | 0.77 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9422801 | 0.77 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6139924-A | CONTAINING A PYRIMIDINE RING | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-10-31 | — | — | US | disclosed |