Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307046 | 0.91 | KDM1A (0.48) | MTNR1AKDM1APTPN1KDM4ECYP1A2 | |
| SCHEMBL28997079 | 0.85 | TGM2 (0.43) | KCNA5KDM4EACHENPC1RAB9A | |
| SCHEMBL9776851 | 0.80 | GRIN2B (0.60) | MTNR1AKDM1APTPN1CYP1A2ADRA2A | |
| SCHEMBL2461761 | 0.79 | MTNR1A (0.59) | MTNR1AKDM4ECYP1A2ADRA2AMAOA | |
| SCHEMBL8177616 | 0.78 | GRIN2B (0.40) | KCNA5KDM4EACHEMAOANPC1 | |
| SCHEMBL23022974 | 0.76 | GRIN2B (0.49) | KDM1AACHEMAOA | |
| SCHEMBL15540736 | 0.76 | GRIN2B (0.49) | KDM1AACHEMAOA | |
| SCHEMBL23023098 | 0.76 | GRIN2B (0.49) | KDM1AACHEMAOA | |
| SCHEMBL8188704 | 0.76 | GRIN2B (0.64) | KDM4EACHEMAOASLC6A2SLC6A4 | |
| SCHEMBL23022842 | 0.75 | KDM1A (0.58) | MTNR1AKDM1AKDM4EACHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117898-A | Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 2000-09-12 | — | — | US | disclosed |
| US-5807886-A | Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0759027-A1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | Astra Aktiebolag (SE) | 1997-02-26 | — | — | EP | disclosed |
| WO-1997006158-A1 | BICYCLIC AMIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1997-02-20 | — | — | WO | disclosed |
| WO-1996001817-A1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AKTIEBOLAG (SE) | 1996-01-25 | — | — | WO | disclosed |