Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629871 | 0.84 | ELANE (0.35) | ALDH1A1TDP1KMT2AKDM4ELMNA | |
| SCHEMBL808527 | 0.81 | ALDH1A1 (0.40) | ALDH1A1TDP1KDM4EGAACYP2A6 | |
| SCHEMBL2252836 | 0.79 | GAA (0.39) | ALDH1A1TDP1KMT2AKDM4ELMNA | |
| SCHEMBL5024317 | 0.78 | GRIN2D (0.34) | ESR1 | |
| SCHEMBL4629536 | 0.77 | KCNH2 (0.42) | ALDH1A1TDP1KMT2AKDM4ELMNA | |
| SCHEMBL2497729 | 0.77 | MAPT (0.34) | ALDH1A1TDP1KDM4EMAPTCYP2A6 | |
| SCHEMBL455640 | 0.77 | CYP2A6 (0.39) | ALDH1A1TDP1CYP2A6TSHRHSD17B10 | |
| SCHEMBL10760575 | 0.76 | KCNH2 (0.44) | ALDH1A1TDP1KMT2AKDM4ELMNA | |
| SCHEMBL5750528 | 0.76 | KCNH2 (0.44) | ALDH1A1TDP1KMT2AKDM4ELMNA | |
| SCHEMBL292073 | 0.76 | KCNH2 (0.44) | ALDH1A1TDP1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147117-A | ADMINISTERING TO AIDS PATIENTS TO TREAT HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS (HIV) | G. D. SEARLE & CO. (US) | 2000-11-14 | — | — | US | disclosed |
| US-6143747-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6060476-A | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2000-05-09 | — | — | US | disclosed |
| US-6046190-A | FOR INHIBITING RETROVIRAL PROTEASES SUCH AS HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5965588-A | COMPOUNDS PARTICULARLY USEFUL AS INHIBITORS OF HIV PROTEASE | G.D. SEARLE & CO. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5843946-A | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-12-01 | — | — | US | disclosed |
| US-5760064-A | RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE (US) | 1998-06-02 | — | — | US | disclosed |
| US-5744481-A | β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-04-28 | — | — | US | disclosed |
| US-5639769-A | ADMINISTERING ANTIVIRAL AGENT | G.D. SEARLE AND CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5521219-A | TREATMENT OF AIDS | G. D. SEARLE & CO. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5510388-A | TREATING HTLV, AIDS | G. D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |