Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177015 | 1.00 | NAAA (0.42) | NAAATMEM97SIGMAR1ROCK2PPARA | |
| SCHEMBL8192360 | 0.99 | NAAA (0.43) | NAAATMEM97SIGMAR1ROCK2PPARA | |
| SCHEMBL1116349 | 0.99 | NAAA (0.43) | NAAATMEM97SIGMAR1ROCK2PPARA | |
| SCHEMBL8192365 | 0.99 | NAAA (0.43) | NAAATMEM97SIGMAR1ROCK2PPARA | |
| SCHEMBL1116363 | 0.99 | NAAA (0.43) | NAAATMEM97SIGMAR1ROCK2PPARA | |
| SCHEMBL436992 | 0.97 | TMEM97 (0.42) | TMEM97SIGMAR1ROCK2KDM4EMEN1 | |
| SCHEMBL436993 | 0.97 | TMEM97 (0.42) | TMEM97SIGMAR1ROCK2KDM4EMEN1 | |
| SCHEMBL6985636 | 0.94 | ROCK2 (0.42) | TMEM97SIGMAR1ROCK2CYP3A4PAK4 | |
| SCHEMBL6985634 | 0.94 | ROCK2 (0.42) | TMEM97SIGMAR1ROCK2CYP3A4PAK4 | |
| SCHEMBL8176218 | 0.90 | TDP1 (0.41) | TMEM97SIGMAR1PPARAPPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000073297-A1 | SUBSTITUTED INDOLINONE AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-12-07 | — | — | WO | disclosed |