Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 1.00 |
| ▸ | MMP13 | P45452 | 3/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | NAT1 | P18440 | 4/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.75 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.75 |
| ▸ | XDH | P47989 | 1/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.70 |
| ▸ | CLK1 | P49759 | 1/20 | 0.70 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.70 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.70 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177661 | 1.00 | MMP3 (1.00) | MMP3MMP13AKR1B1HPGDNAT1 | |
| SCHEMBL18103088 | 1.00 | MMP3 (1.00) | MMP3MMP13AKR1B1HPGDNAT1 | |
| SCHEMBL1300557 | 0.88 | HPGD (1.00) | MMP3MMP13AKR1B1HPGDXDH | |
| SCHEMBL1249023 | 0.88 | HPGD (1.00) | MMP3MMP13AKR1B1HPGDXDH | |
| SCHEMBL1249025 | 0.88 | HPGD (1.00) | MMP3MMP13AKR1B1HPGDXDH | |
| SCHEMBL8308267 | 0.88 | MMP13 (1.00) | MMP3MMP13AKR1B1NAT1CA2 | |
| SCHEMBL1248886 | 0.88 | MMP13 (1.00) | MMP3MMP13AKR1B1NAT1CA2 | |
| SCHEMBL1248883 | 0.88 | MMP13 (1.00) | MMP3MMP13AKR1B1NAT1CA2 | |
| SCHEMBL18095832 | 0.87 | NAT1 (0.83) | MMP3MMP13AKR1B1HPGDNAT1 | |
| SCHEMBL18103024 | 0.87 | NAT1 (0.83) | MMP3MMP13AKR1B1HPGDNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | claimed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | claimed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | claimed |
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |