Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186274 | 0.78 | ALDH1A1 (0.44) | L3MBTL1POLBTDP1NOTUMCYP2C9 | |
| SCHEMBL8178332 | 0.78 | GSK3A (0.50) | L3MBTL1TDP1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL29191759 | 0.73 | GAA (0.54) | KMT2ANOTUMDAOCYP2C9CYP2C19 | |
| SCHEMBL8177807 | 0.71 | NOTUM (0.41) | L3MBTL1POLBTDP1NOTUMCYP1A2 | |
| SCHEMBL15077184 | 0.68 | HTT (0.54) | POLBTDP1NOTUMNR1H4NPC1 | |
| SCHEMBL8177459 | 0.68 | CYP1A2 (0.74) | L3MBTL1POLBKMT2ANOTUMCYP1A2 | |
| SCHEMBL5905952 | 0.68 | CYP1A2 (0.69) | L3MBTL1POLBTDP1NOTUMCYP1A2 | |
| SCHEMBL8602716 | 0.67 | SMN1; SMN2 (0.40) | POLBTDP1NOTUMDAONPC1 | |
| SCHEMBL23643217 | 0.66 | GSK3A (0.54) | POLBKMT2ACYP2C9CYP2C19NR1H4 | |
| SCHEMBL9696181 | 0.66 | GSK3A (0.44) | L3MBTL1POLBTDP1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |