Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186274 | 0.81 | ALDH1A1 (0.44) | GSK3AGSK3BL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL8177809 | 0.80 | CYP1A2 (0.46) | GAARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL8186401 | 0.79 | TDP1 (0.40) | NPC1RAB9AL3MBTL1CYP1A2TDP1 | |
| SCHEMBL8178131 | 0.78 | L3MBTL1 (0.42) | NPC1RAB9AL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL8177459 | 0.77 | CYP1A2 (0.74) | GAAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL3520528 | 0.77 | L3MBTL1 (0.66) | GSK3AGSK3BGAANPC1RAB9A | |
| SCHEMBL3167625 | 0.76 | MAPK9 (0.56) | GSK3AGSK3BGAANPC1RAB9A | |
| SCHEMBL8185171 | 0.74 | L3MBTL1 (0.72) | NPC1RAB9AL3MBTL1SMN1; SMN2CYP1A2 | |
| SCHEMBL8185793 | 0.74 | CYP1A2 (0.54) | NPC1RAB9AL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL8177807 | 0.74 | NOTUM (0.41) | L3MBTL1ALDH1A1SMN1; SMN2CYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |