Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 5/20 | 0.52 |
| ▸ | HPGDS | O60760 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10160852 | 0.83 | CYP11B1 (0.56) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| Hydrochloric Acid SCHEMBL15940913 | 0.81 | LTA4H (0.56) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| SCHEMBL10722497 | 0.80 | CYP11B1 (0.53) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| SCHEMBL10130808 | 0.79 | CYP11B1 (0.52) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| SCHEMBL13514078 | 0.79 | CYP11B1 (0.52) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| SCHEMBL485305 | 0.79 | FYN (0.45) | CYP11B1CYP11B2FYNHPGDSKDM4E | |
| SCHEMBL10726790 | 0.78 | RAB9A (0.52) | CYP11B1CYP11B2HPGDSKDM4EALDH1A1 | |
| SCHEMBL29258492 | 0.77 | KDM1A (0.43) | CYP11B1CYP11B2FYNMAPTNPC1 | |
| SCHEMBL10723314 | 0.76 | RAB9A (0.52) | CYP11B1CYP11B2HPGDSKDM4EALDH1A1 | |
| SCHEMBL12727899 | 0.76 | KDM4E (0.52) | CYP11B1CYP11B2FYNHPGDSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051574-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-5883105-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0891357-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036898-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |