Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192428 | 0.87 | MAPK8 (0.66) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL4789253 | 0.85 | MAPK8 (0.67) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL8186280 | 0.83 | MAPK8 (0.64) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL8187604 | 0.82 | MAPK8 (0.69) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL8187444 | 0.81 | MAPK8 (0.67) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL8178294 | 0.80 | MAPK8 (0.61) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL8044444 | 0.80 | ALDH1A1 (0.44) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL4789242 | 0.79 | MAPK8 (0.68) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL31090329 | 0.79 | MAPK8 (0.67) | MAPK8MAPK9MAPK10HTTNPC1 | |
| SCHEMBL31090332 | 0.79 | MAPK8 (0.67) | MAPK8MAPK9MAPK10HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |