Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 9/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675872 | 0.85 | MAPK1 (0.51) | L3MBTL1MAPTGABRA5ALDH1A1MAPK1 | |
| SCHEMBL16422737 | 0.82 | MAPT (0.48) | L3MBTL1MAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7952665 | 0.80 | CA1 (0.39) | L3MBTL1MAPTALDH1A1 | |
| SCHEMBL12500730 | 0.79 | TDP1 (0.43) | L3MBTL1MAPTALDH1A1HPGDPOLB | |
| SCHEMBL2302456 | 0.78 | L3MBTL1 (0.66) | L3MBTL1MAPTP4HA1P4HTMMIF | |
| SCHEMBL6829621 | 0.78 | L3MBTL1 (0.41) | L3MBTL1MAPTP4HA1P4HTMMIF | |
| SCHEMBL30112060 | 0.78 | L3MBTL1 (0.66) | L3MBTL1MAPTP4HA1P4HTMMIF | |
| SCHEMBL30832531 | 0.78 | CXCR2 (0.36) | L3MBTL1GABRA5ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL16548489 | 0.77 | KDM4E (0.40) | L3MBTL1MAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL1017950 | 0.77 | PDE4A (0.42) | L3MBTL1MAPTALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051574-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-5883105-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-03-16 | — | — | US | disclosed |
| US-5880140-A | Biheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0891351-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0891357-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036898-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| WO-1997036890-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |