Acetic Acid

Acetic Acid

SCHEMBL8178315

CC(=O)O.NC(=O)CC(CO)c1ccccc1

nearest known ligand 0.54

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MC4R known ✓ P32245 1/20 0.42
ALDH1A1 P00352 1/20 0.54
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
PKM P14618 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
GABBR2 O75899 2/20 0.49
GABBR1 Q9UBS5 2/20 0.49
CYP2C19 P33261 4/20 0.46
SLC6A3 Q01959 3/20 0.42
DRD3 P35462 2/20 0.42
LMNA P02545 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
EDNRB P24530 1/20 0.42
MAPK1 P28482 1/20 0.42
MC3R P41968 1/20 0.42
DRD2 P14416 1/20 0.42
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL8188055 1.00 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
Acetic Acid SCHEMBL8177844 1.00 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
SCHEMBL8187229 0.94 CYP2D6 (0.56) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
SCHEMBL8192677 0.94 CYP2D6 (0.56) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
SCHEMBL1059563 0.94 CYP2D6 (0.56) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
Sulfamate SCHEMBL8177851 0.86 CYP1A2 (0.49) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
Sulfamate SCHEMBL8187381 0.86 CYP1A2 (0.49) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
Sulfamate SCHEMBL8188608 0.86 CYP1A2 (0.49) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
SCHEMBL9105247 0.85 ALDH1A1 (0.63) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2
SCHEMBL16588649 0.84 ALDH1A1 (0.59) ALDH1A1CYP1A2CYP2D6PKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801642-B1 NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME YUKONG LTD (KR) 2000-12-20 EP disclosed
US-5892088-A Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same YUKONG LIMITED (KR) 1999-04-06 US disclosed
EP-0801642-A1 NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME YUKONG LIMITED (KR) 1997-10-22 EP disclosed
WO-1997016418-A1 NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME YUKONG LIMITED (KR) 1997-05-09 WO disclosed