Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180123 | 0.91 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL8183118 | 0.90 | ALDH1A1 (0.59) | ALDH1A1LMNAMAPTALOX15HTT | |
| Bicarbonate SCHEMBL7016458 | 0.89 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8178383 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8180824 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8170169 | 0.85 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8179115 | 0.83 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8184348 | 0.82 | HTT (0.49) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL8181994 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8180882 | 0.81 | PDE10A (0.53) | ALDH1A1LMNAMAPTALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |