Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | GSK3B | P49841 | 5/20 | 0.56 |
| ▸ | GSK3A | P49840 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179019 | 0.92 | KDM4E (0.59) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8186789 | 0.91 | KDM4E (0.64) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8187896 | 0.90 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8194355 | 0.88 | KDM4E (0.55) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8186808 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8188863 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL7814828 | 0.83 | GSK3B (0.69) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL7815046 | 0.80 | KMT2A (0.70) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL8189185 | 0.79 | KDM4E (0.51) | ALDH1A1KDM4EHPGDGAAGSK3B | |
| SCHEMBL2746217 | 0.78 | L3MBTL1 (0.69) | ALDH1A1KDM4EHPGDGAAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162918-A | Xanthene and acridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2000-12-19 | — | — | US | disclosed |
| US-5969139-A | INHIBITORS OF HERPES SIMPLEX VIRUS THYMIDINE KINASE | HOFFMANN-LA ROCHE INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0823426-A1 | Xanthene and acridine derivatives and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-11 | — | — | EP | disclosed |