Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170324 | 0.90 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8170042 | 0.80 | MAPT (0.43) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL6762819 | 0.80 | KMT2A (0.45) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8177925 | 0.78 | POLB (0.55) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8179509 | 0.78 | MAPT (0.46) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8178257 | 0.78 | PRKCI (0.45) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL5119506 | 0.77 | PRKCI (0.57) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8179294 | 0.77 | CA1 (0.49) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8169989 | 0.76 | KDM4E (0.53) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL8169721 | 0.76 | KDM4E (0.45) | KDM4EMAPTALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |