Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | APP | P05067 | 5/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169994 | 0.93 | MEN1 (0.50) | MEN1KMT2AACHEAPPBCHE | |
| SCHEMBL8183537 | 0.92 | PDE5A (0.45) | MEN1KMT2A | |
| SCHEMBL8179380 | 0.88 | MEN1 (0.54) | MEN1KMT2AACHEAPPBCHE | |
| SCHEMBL8180525 | 0.87 | MEN1 (0.56) | MEN1KMT2AACHEAPPBCHE | |
| SCHEMBL5118831 | 0.87 | MEN1 (0.53) | MEN1KMT2AACHEAPPBCHE | |
| SCHEMBL8178327 | 0.86 | MEN1 (0.55) | MEN1KMT2AACHEAPPBCHE | |
| SCHEMBL8178620 | 0.86 | LMNA (0.47) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL8183034 | 0.85 | PDE5A (0.45) | MEN1KMT2A | |
| SCHEMBL8183760 | 0.85 | CYP1A2 (0.51) | MEN1KMT2ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL8183027 | 0.85 | USP1 (0.48) | MEN1KMT2AMAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |