Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 16/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177997 | 0.91 | PTGS2 (0.61) | PTGS2PRKCIPRKCZSMN1; SMN2KDM4E | |
| SCHEMBL8180415 | 0.91 | PTGS2 (0.63) | PTGS2PRKCIPRKCZSMN1; SMN2KDM4E | |
| SCHEMBL8176873 | 0.86 | PRKCI (0.50) | PTGS2PRKCISMN1; SMN2HTT | |
| SCHEMBL5781941 | 0.84 | PRKCI (0.74) | PRKCIPRKCZ | |
| SCHEMBL8184514 | 0.84 | PTGS2 (0.58) | PTGS2PRKCISMN1; SMN2MEN1MAPT | |
| SCHEMBL8181051 | 0.82 | PRKCI (0.51) | PRKCISMN1; SMN2KDM4EHTT | |
| SCHEMBL8179988 | 0.81 | PTGS2 (0.65) | PTGS2PRKCIPRKCZSMN1; SMN2KDM4E | |
| SCHEMBL8186810 | 0.81 | PTGS2 (0.55) | PTGS2PRKCIPRKCZ | |
| SCHEMBL8186191 | 0.81 | PRKCI (0.43) | PRKCISMN1; SMN2KDM4EMEN1TP53 | |
| SCHEMBL8185547 | 0.81 | PTGS2 (0.51) | PTGS2PRKCISMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |