Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603903 | 0.98 | HRH1 (0.47) | HRH1ACHES1PR5SIGMAR1CHRM1 | |
| SCHEMBL7609346 | 0.92 | HRH1 (0.43) | HRH1ACHESIGMAR1CHRM1 | |
| SCHEMBL7609166 | 0.91 | HRH1 (0.48) | HRH1ACHESIGMAR1CHRM1DRD3 | |
| Hydrochloric Acid SCHEMBL8182026 | 0.90 | HRH1 (0.47) | HRH1ACHESIGMAR1CHRM1 | |
| SCHEMBL7783140 | 0.86 | CHRM1 (0.49) | HRH1ACHESIGMAR1CHRM1 | |
| SCHEMBL7611480 | 0.85 | SIGMAR1 (0.47) | HRH1SIGMAR1CHRM1CHRM2CHRM3 | |
| SCHEMBL7604912 | 0.85 | HRH1 (0.44) | HRH1ACHESIGMAR1CHRM1 | |
| SCHEMBL7605268 | 0.84 | SIGMAR1 (0.48) | HRH1ACHESIGMAR1 | |
| SCHEMBL8180481 | 0.84 | DRD2 (0.43) | HRH1ACHESIGMAR1CHRM1CHRM2 | |
| SCHEMBL7603087 | 0.84 | HRH1 (0.45) | HRH1ACHESIGMAR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114354-A | N-substituted azaheterocyclic compounds | NOVO NORDISK A/S (DK) | 2000-09-05 | — | — | US | disclosed |
| US-6100253-A | 3-(1-(3-(XANTHEN-9-YLIDENE)-1-PROPYL)PIPERIDIN-4-YL)PROPIONIC ACID, FOR EXAMPLE; TREATING NON-INSULIN DEPENDENT DIABETES, NEUROGENIC INFLAMMATION AND OBESITY; INTERFERE WITH C-FIBERS TO INHIBIT SECRETION OF INSULIN ANTAGONISING PEPTIDES | NOVO NORDISK A/S (DK) | 2000-08-08 | — | — | US | disclosed |
| US-6066632-A | ANALGESICS; ANTIINFLAMMATORY AGENTS | NOVO NORDISK A/S (DK) | 2000-05-23 | — | — | US | disclosed |
| EP-0991621-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 2000-04-12 | — | — | EP | disclosed |
| US-6040318-A | TREATING INSULIN RESISTANT NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY, NEUROGENIC INFLAMMATION ASSOCIATED WITH NEUROPATHY OR RHEUMATOID ARTHRITIS | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| WO-1999000367-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1999-01-07 | — | — | WO | disclosed |