Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628672 | 0.84 | TSHR (0.60) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL26586781 | 0.83 | CES2 (0.39) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL30755337 | 0.83 | TSHR (0.57) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL14048740 | 0.83 | TSHR (0.53) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL1997075 | 0.83 | TSHR (0.60) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL10562029 | 0.83 | TSHR (0.57) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL11933660 | 0.81 | TSHR (0.56) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL14841131 | 0.81 | CA12 (0.57) | TSHRKDM4ELMNASMN1; SMN2POLB | |
| SCHEMBL3895996 | 0.81 | CA12 (0.70) | TSHRKDM4ELMNASMN1; SMN2TDP1 | |
| SCHEMBL1151008 | 0.81 | SLC6A4 (0.47) | TSHRKDM4ELMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133286-A | ANTAGONISTS; ANTIINFLAMMATORY AGENTS FOR RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, PSORIASIS AND OTHER SKIN DISORDERS, E.G., ECZEMA, ERYTHEMA, PRURITUS AND ACNE; STROKE, REPERFUSION INJURY, GRAFTING | PFIZER INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6051601-A | USEFUL OF INFLAMMATORY DISORDERS INCLUDING RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, PSORIASIS AND OTHER SKIN DISORDERS SUCH AS ECZEMA, ERYTHEMA, PRURITUS AND ACNE, STROKE AND OTHER FORMS OF REPERFUSLON | PFIZER INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-5939452-A | TREATMENT OF ANTIINFLAMMATORY SKIN DISORDERS, AUTOIMMUNE DISORDERS | PFIZER INC (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0785935-A1 | BENZOPYRAN AND BENZO-FUSED COMPOUNDS, THEIR PREPARATION AND THEIR USE AS LEUKOTRIENE B4' (LTB4) ANTAGONISTS | PFIZER INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| EP-0785930-A1 | BENZOPYRAN AND BENZO-FUSED COMPOUNDS, THEIR PREPARATION AND THEIR USE AS LEUKOTRIENE B 4? (LTB 4?) ANTAGONISTS | PFIZER INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011925-A1 | BENZOPYRAN AND BENZO-FUSED COMPOUNDS, THEIR PREPARATION AND THEIR USE AS LEUKOTRIENE B4' (LTB4) ANTAGONISTS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |
| WO-1996011920-A1 | BENZOPYRAN AND BENZO-FUSED COMPOUNDS, THEIR PREPARATION AND THEIR USE AS LEUKOTRIENE B4 (LTB4) ANTAGONISTS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |