Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10524671 | 0.85 | MAPT (0.40) | CETPHSPB1MAPTEPAS1HTT | |
| SCHEMBL1997338 | 0.83 | TLR4 (0.46) | CETPHSPB1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL640851 | 0.78 | L3MBTL1 (0.51) | HSPB1SLC6A4SLC6A3SLC6A2MAPT | |
| SCHEMBL17203988 | 0.76 | EPAS1 (0.51) | CETPHSPB1MAPTEPAS1TLR8 | |
| SCHEMBL30856930 | 0.74 | EPAS1 (0.63) | CETPHSPB1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL16556058 | 0.74 | EPAS1 (0.63) | CETPHSPB1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8673436 | 0.74 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2PARP10TRPV1 | |
| SCHEMBL29791297 | 0.74 | MAPT (0.43) | CETPHSPB1MAPTEPAS1HTT | |
| SCHEMBL6117 | 0.73 | TDP1 (0.53) | HSPB1MAPTHTTMEN1KMT2A | |
| SCHEMBL30297160 | 0.73 | TDP1 (0.53) | HSPB1MAPTHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043284-A | ACYL COENZYME A: CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS | GLAXO WELLCOME INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5776951-A | ANTICHOLESTEROL AGENT | GLAXO WELLCOME INC. (US) | 1998-07-07 | — | — | US | disclosed |