SCHEMBL8181768

SCHEMBL8181768

CC(C)CCCCCCCCCCCC(O)CC=O

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.37
KDM4C Q9H3R0 2/20 0.37
KDM4A O75164 1/20 0.37
PHF8 Q9UPP1 1/20 0.37
KDM2A Q9Y2K7 1/20 0.37
FFAR1 O14842 2/20 0.37
FFAR4 Q5NUL3 2/20 0.37
GPR84 Q9NQS5 5/20 0.35
HIF1A Q16665 1/20 0.35
EPAS1 Q99814 1/20 0.35
ACACB O00763 1/20 0.34
ACACA Q13085 1/20 0.34
FAAH O00519 2/20 0.33
TRPV1 Q8NER1 1/20 0.33
TRPA1 O75762 1/20 0.33
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27215948 1.00 LMNA (0.37) LMNAKDM4CKDM4APHF8KDM2A
SCHEMBL1784320 1.00 LMNA (0.37) LMNAKDM4CKDM4APHF8KDM2A
SCHEMBL1783444 0.98 LMNA (0.39) LMNAKDM4CKDM4APHF8KDM2A
SCHEMBL1783360 0.93 LMNA (0.39) LMNAKDM4CKDM4APHF8KDM2A
SCHEMBL1781193 0.84 CA1 (0.32)
SCHEMBL9324211 0.83 GPR84 (0.53) FFAR1FFAR4GPR84FAAHTRPA1
SCHEMBL1783522 0.83 GPR84 (0.53) FFAR1FFAR4GPR84FAAHTRPA1
SCHEMBL1781773 0.83 GPR84 (0.53) FFAR1FFAR4GPR84FAAHTRPA1
SCHEMBL21051773 0.83 GPR84 (0.53) FFAR1FFAR4GPR84FAAHTRPA1
SCHEMBL21051774 0.83 GPR84 (0.53) FFAR1FFAR4GPR84FAAHTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6110933-A AN ENZYME INHIBITOR TREATING PANCREATITIS, HEPATITIS, CHRONIC RENAL FAILURE, ENDOTOXIN SHOCK, GRAM-NEGATIVE SEPTIC SHOCK, ARTHRITIS, RESPIRATORY DISEASE, HEART DISEASE, ALLERGIC DISEASE, THROMBOSIS, ARTERIOSCLEROSIS, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-29 US disclosed
EP-0741697-B1 AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS FUJISAWA PHARMACEUTICAL CO (JP) 1999-09-15 EP disclosed
EP-0741697-A1 AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-11-13 EP disclosed
WO-1995019959-A1 AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-07-27 WO disclosed