Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31298196 | 0.83 | DGAT1 (0.34) | BRD4DGAT1MAPTEGFRIGF1R | |
| SCHEMBL18789133 | 0.83 | MKNK1 (0.42) | BRD4DGAT1MAPTEGFRIGF1R | |
| SCHEMBL31298152 | 0.82 | KDR (0.37) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL19832096 | 0.82 | KDR (0.37) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL8472530 | 0.82 | DGAT1 (0.39) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL19832083 | 0.82 | JAK2 (0.40) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL8470002 | 0.81 | DGAT1 (0.36) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL2753800 | 0.81 | DGAT1 (0.41) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL3347313 | 0.81 | DGAT1 (0.36) | BRD4DGAT1EGFRIGF1RSRC | |
| SCHEMBL3355528 | 0.81 | KDR (0.41) | BRD4DGAT1EGFRIGF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |