Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472530 | 0.88 | DGAT1 (0.39) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL2753800 | 0.87 | DGAT1 (0.41) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL3347313 | 0.87 | DGAT1 (0.36) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL3346630 | 0.85 | BRD4 (0.37) | DGAT1BRD4CREBBPLRRK2SRC | |
| SCHEMBL13539153 | 0.85 | DGAT1 (0.35) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL3349611 | 0.84 | BRD4 (0.36) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL3352910 | 0.83 | CYP19A1 (0.35) | DGAT1BRD4CREBBP | |
| SCHEMBL3353967 | 0.83 | MET (0.40) | DGAT1BRD4CREBBPLRRK2EGFR | |
| SCHEMBL8445038 | 0.83 | CHUK (0.37) | DGAT1BRD4CREBBPEGFRIGF1R | |
| SCHEMBL3352871 | 0.83 | DGAT1 (0.36) | DGAT1BRD4CREBBPLRRK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |