Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188875 | 0.87 | ALDH1A1 (0.47) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8174496 | 0.87 | GAA (0.46) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8180703 | 0.84 | CRHR1 (0.41) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8183587 | 0.84 | MAPT (0.43) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8182205 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8182279 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8183813 | 0.84 | GAA (0.44) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8173412 | 0.84 | KDM4E (0.43) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8182995 | 0.83 | KDM4E (0.52) | KDM4EALDH1A1RAB9AHSD17B10NPC1 | |
| SCHEMBL8181054 | 0.83 | ALDH1A1 (0.40) | KDM4EALDH1A1RAB9AHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103736-A | SHOWING AN INHIBITORY ACTION ON GASTRIC ACID SECRETION AND A PROTECTIVE ACTION OF GASTRIC MUCOSA; 2-(HETERO)ARYL-3-AMINOIMIDAZO-(2,1-A)ISOQUINOLINES; ANTIULCER AGENTS; | SHINNIPPON PHARMACEUTICAL INC. (JP) | 2000-08-15 | — | — | US | disclosed |
| US-6020342-A | Fused imidazo[1,2-A]pyridines | SHINNIPPON PHARMACEUTICAL, INC. (JP) | 2000-02-01 | — | — | US | disclosed |
| EP-0822194-A1 | FUSED IMIDAZO 1,2-a]PYRIDINES | Shinnippon Pharmaceutical Inc. (JP) | 1998-02-04 | — | — | EP | disclosed |