Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 12/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | TDP2 | O95551 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | PNP | P00491 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8183002 | 1.00 | TDP1 (0.70) | TDP1GSK3BTDP2MEN1KMT2A | |
| SCHEMBL14860977 | 0.82 | TDP1 (1.00) | TDP1TDP2MAPTRECQLPNP | |
| SCHEMBL14860975 | 0.82 | TDP1 (1.00) | TDP1TDP2MAPTRECQLPNP | |
| SCHEMBL14860979 | 0.82 | TDP1 (1.00) | TDP1TDP2MAPTRECQLPNP | |
| SCHEMBL19659989 | 0.82 | CA2 (0.71) | GSK3BMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL19999122 | 0.82 | CA2 (0.71) | GSK3BMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2684658 | 0.79 | RAB9A (0.74) | TDP1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4568730 | 0.79 | RAB9A (0.74) | TDP1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2684656 | 0.79 | RAB9A (0.74) | TDP1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8186860 | 0.78 | MEN1 (0.68) | TDP1MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |