Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 10/20 | 0.65 |
| ▸ | CNR2 | P34972 | 4/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.60 |
| ▸ | CNR1 | P21554 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.60 |
| ▸ | RXRA | P19793 | 1/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.60 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306487 | 0.94 | AKR1B1 (0.63) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL7784043 | 0.86 | AKR1B1 (0.72) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL9558541 | 0.84 | GABRA1 (0.63) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL13978642 | 0.84 | AKR1B1 (0.74) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL13287275 | 0.82 | GABRA1 (0.78) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL8498307 | 0.81 | MCL1 (0.55) | AKR1B1ALOX5MCL1APPPDK2 | |
| SCHEMBL4907630 | 0.80 | AKR1B1 (1.00) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL252293 | 0.80 | GABRA1 (1.00) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL29892631 | 0.80 | GABRA1 (1.00) | AKR1B1GABRA1GABRB2CNR2ALOX5 | |
| SCHEMBL2185735 | 0.79 | GABRA1 (0.82) | AKR1B1GABRA1GABRB2CNR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080870-A | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors | MERCK & CO., INC. (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |