Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 7/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GLB1 | P16278 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181124 | 0.95 | GBA1 (0.54) | PYGLGBA1BCHEACHE | |
| SCHEMBL8187378 | 0.95 | GBA1 (0.54) | PYGLGBA1BCHEACHE | |
| SCHEMBL8176411 | 0.89 | PYGL (0.69) | PYGLGBA1SIGMAR1 | |
| SCHEMBL8172188 | 0.88 | GBA1 (0.58) | PYGLGBA1 | |
| SCHEMBL440211 | 0.84 | GBA1 (0.66) | PYGLGBA1 | |
| SCHEMBL2454394 | 0.84 | GBA1 (0.66) | PYGLGBA1 | |
| SCHEMBL403643 | 0.84 | GBA1 (0.66) | PYGLGBA1 | |
| SCHEMBL8181071 | 0.83 | PYGL (0.49) | PYGLGBA1SIGMAR1 | |
| SCHEMBL8187072 | 0.82 | GBA1 (0.47) | PYGLGBA1 | |
| SCHEMBL14388983 | 0.81 | GBA1 (0.59) | PYGLGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046214-A | USEFUL IN TREATMENT AND/OR PREVENTION OF DIABETES, AND ESPECIALLY NON-INSULIN DEPENDENT DIABETES (NIDDM OR TYPE 2 DIABETES) INCLUDING OVERNIGHT OR MEAL TREATMENT AND TREATMENT OR PREVENTION OF LONGTERM COMPLICATIONS, SUCH AS RETINOPATHY | NOVO NORDISK A/S (DK) | 2000-04-04 | — | — | US | disclosed |
| EP-0983239-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050359-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-11-12 | — | — | WO | disclosed |