Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.34 |
| ▸ | ITGAV | P06756 | 6/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615317 | 0.92 | ALDH1A1 (0.32) | ITGB3ITGB1ITGAVITGA5ALDH1A1 | |
| SCHEMBL8185334 | 0.90 | FNTA (0.39) | FNTAFNTBPGGT1B | |
| SCHEMBL8185291 | 0.88 | ITGB3 (0.33) | ITGB3ITGB1ITGAVITGA5ALDH1A1 | |
| SCHEMBL7562561 | 0.86 | ITGB3 (0.33) | ITGB3ITGB1ITGAVITGA5ALDH1A1 | |
| SCHEMBL7561738 | 0.86 | ITGB3 (0.33) | ITGB3ITGB1ITGAVITGA5ALDH1A1 | |
| SCHEMBL8197252 | 0.85 | ALDH1A1 (0.32) | ITGB3ITGB1ITGAVITGA5ALDH1A1 | |
| SCHEMBL7610663 | 0.85 | BRS3 (0.35) | CAPN1 | |
| SCHEMBL8197256 | 0.84 | FNTA (0.32) | ALDH1A1FNTAFNTBPGGT1B | |
| SCHEMBL8186039 | 0.83 | MAPK8 (0.34) | ALDH1A1CAPN1 | |
| SCHEMBL7591164 | 0.83 | FNTA (0.35) | ITGB3ITGB1ITGAVITGA5FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-09 | — | — | EP | claimed |
| WO-1999020611-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-04-29 | — | — | WO | claimed |
| EP-1025088-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020611-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |