Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190334 | 0.94 | HRH3 (0.58) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8190341 | 0.90 | HRH3 (0.56) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8184976 | 0.89 | S1PR5 (0.60) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8190422 | 0.85 | HRH3 (0.52) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL10571355 | 0.85 | HRH3 (0.54) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8189400 | 0.85 | HRH3 (0.49) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8187058 | 0.84 | ADRA2A (0.57) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8187259 | 0.83 | HRH3 (0.58) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL8176552 | 0.83 | S1PR5 (0.60) | S1PR5HRH3ADRA2AADRA2BADRA2C | |
| Ammonia Solution, Strong SCHEMBL8185454 | 0.83 | ADRA2A (0.56) | S1PR5HRH3ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096752-A | Method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives | HEINONEN PETRI (FI) | 2000-08-01 | — | — | US | disclosed |
| US-5912342-A | SYNTHESIS OF COMBINATORIAL LIBRARIES BY COMPUTER CONTROLLED ROBOT | HEINONEN PETRI (FI) | 1999-06-15 | — | — | US | disclosed |
| EP-0910562-A2 | A METHOD FOR THE PREPARATION OF TERTIARY AMINES, A COMPOUND USEFUL THEREFOR AND ALPHA-2-RECEPTOR ACTIVE TETRAHYDROISOQUINOLINE DERIVATIVES | Oy Juvantia Pharma Ltd (FI) | 1999-04-28 | — | — | EP | disclosed |
| WO-1998051672-A2 | A METHOD FOR THE PREPARATION OF TERTIARY AMINES, A COMPOUND USEFUL THEREFOR AND ALPHA-2-RECEPTOR ACTIVE TETRAHYDROISOQUINOLINE DERIVATIVES | OY JUVANTIA PHARMA LTD. (FI) | 1998-11-19 | — | — | WO | disclosed |