Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185466 | 1.00 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8189815 | 0.90 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8189808 | 0.90 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8187016 | 0.77 | HRH3 (0.56) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL25907679 | 0.76 | DRD1 (0.54) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8187259 | 0.76 | HRH3 (0.58) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8184418 | 0.75 | CHRNA7 (0.61) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL8187075 | 0.75 | DRD2 (0.52) | ADRA2AADRA2BADRA2CPRMT5WDR77 | |
| SCHEMBL5568684 | 0.74 | DRD1 (0.77) | ADRA2AADRA2BADRA2CDRD2DRD1 | |
| SCHEMBL8192779 | 0.74 | HRH3 (0.53) | ADRA2AADRA2BADRA2CPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096752-A | Method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives | HEINONEN PETRI (FI) | 2000-08-01 | — | — | US | disclosed |
| US-5912342-A | SYNTHESIS OF COMBINATORIAL LIBRARIES BY COMPUTER CONTROLLED ROBOT | HEINONEN PETRI (FI) | 1999-06-15 | — | — | US | disclosed |
| EP-0910562-A2 | A METHOD FOR THE PREPARATION OF TERTIARY AMINES, A COMPOUND USEFUL THEREFOR AND ALPHA-2-RECEPTOR ACTIVE TETRAHYDROISOQUINOLINE DERIVATIVES | Oy Juvantia Pharma Ltd (FI) | 1999-04-28 | — | — | EP | disclosed |
| WO-1998051672-A2 | A METHOD FOR THE PREPARATION OF TERTIARY AMINES, A COMPOUND USEFUL THEREFOR AND ALPHA-2-RECEPTOR ACTIVE TETRAHYDROISOQUINOLINE DERIVATIVES | OY JUVANTIA PHARMA LTD. (FI) | 1998-11-19 | — | — | WO | disclosed |