Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186114 | 0.94 | PDE5A (0.48) | KDM4EPDE5APOLB | |
| SCHEMBL8181251 | 0.91 | PDE4A (0.46) | ALDH1A1MAPTTP53PDE5ACASP6 | |
| SCHEMBL7019169 | 0.90 | PDE5A (0.39) | ALDH1A1MEN1KMT2AATMMAPT | |
| SCHEMBL8177701 | 0.89 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AATMTP53 | |
| SCHEMBL8179215 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPTTP53HTTL3MBTL1 | |
| SCHEMBL8184659 | 0.89 | MAPT (0.45) | ALDH1A1KMT2AMAPTTP53HTT | |
| SCHEMBL8185688 | 0.89 | CTNNB1 (0.46) | ALDH1A1MAPTTP53HTT | |
| SCHEMBL8170704 | 0.89 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AATMMAPT | |
| SCHEMBL8180271 | 0.89 | CTNNB1 (0.44) | ALDH1A1MAPTTP53HTTCTSB | |
| SCHEMBL8181123 | 0.88 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |