Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165226 | 0.86 | CYP11B1 (0.37) | CYP1A2CYP2D6CYP19A1ALDH1A1HRH3 | |
| SCHEMBL6167672 | 0.82 | HRH4 (0.46) | CYP1A2CYP2D6HRH3CYP11B1CYP11B2 | |
| SCHEMBL1201603 | 0.82 | KCNH2 (0.41) | TAAR1CYP1A2CYP2D6MAOAMAOB | |
| SCHEMBL19689361 | 0.79 | HTR2A (0.42) | ADRA2AADRA1AMAOAMAOB | |
| SCHEMBL5683250 | 0.75 | — | — | |
| SCHEMBL6165479 | 0.75 | SMN1; SMN2 (0.44) | TAAR1LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL1189016 | 0.73 | IDO1 (0.39) | TAAR1LMNA | |
| SCHEMBL855159 | 0.72 | CALM1 (0.41) | CALM1TAAR1LMNASORT1CYP19A1 | |
| SCHEMBL5683854 | 0.71 | — | — | |
| SCHEMBL1243875 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 356 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101312948-B | Biaryl substituted heterocycle inhibitors of lTA4H for treating inflammation | DECODE GENETICS EHF | 2015-01-14 | — | — | CN | claimed |
| EP-1278720-B1 | 1,4-DIARYL-2-FLUORO-4-CYANO-2-BUTENES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES USEFUL THEREFOR | BASF AG (DE) | 2005-04-06 | — | — | EP | claimed |
| EP-1006110-B8 | DERIVATIVES OF ACYL-PIPERAZINIL-PYRIMIDINS, PREPARATION THEREOF AND APPLICATION AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2005-01-05 | — | — | EP | claimed |
| EP-1144305-A4 | NOVEL sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2004-11-10 | — | — | EP | claimed |
| US-6770463-B2 | INSECTICIDES AND ACARICIDES; AROMATIC SUBSTITUTED HALOALKENES | BASF AKTIENGESELLSCHAFT (DE) | 2004-08-03 | — | — | US | claimed |
| US-20040029948-A1 | Novel sPLA2 inhibitors | HARPER RICHARD WALTZ (US) | 2004-02-12 | — | — | US | claimed |
| EP-1202948-B1 | PROCESSES FOR THE PREPARATION OF 2-ARYLVINYL ALKYL ETHER AND 1,4-DIARYL-2-FLUORO-2-BUTENE COMPOUNDS | BASF AG (DE) | 2003-12-10 | — | — | EP | claimed |
| EP-1131273-B1 | 1,4-DIARYL-2-FLUORO-1-BUTEN-3-OL COMPOUNDS AND THEIR USE IN THE PREPARATION OF 1,4-DIARYL-2-FLUORO-1,3-BUTADIENE AND 1,4-DIARYL-2-FLUORO-2-BUTENE COMPOUNDS | BASF AG (DE) | 2003-10-22 | — | — | EP | claimed |
| EP-1351913-A2 | 1,4-DIARYL-2,3-DIFLUORO-2-BUTENE INSECTICIDAL AND ACARICIDAL AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2003-10-15 | — | — | EP | claimed |
| US-20030191175-A1 | Indole sPLA2 inhibitors | MIHELICH EDWARD DAVID (US) | 2003-10-09 | — | — | US | claimed |
| WO-1999005121-A1 | DERIVATIVES OF ACYL-PIPERAZINIL-PYRIMIDINS, PREPARATION THEREOF AND APPLICATION AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1999-02-04 | — | — | WO | claimed |
| WO-1998008813-A1 | COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | claimed |
| US-5710102-A | Difluorovinylsilane insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY (US) | 1998-01-20 | — | — | US | claimed |
| EP-0811593-A1 | 1,4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | claimed |
| EP-0796860-A2 | Difluorvinylsilane insecticidal and acaridal agents | American Cyanamid Company (US) | 1997-09-24 | — | — | EP | claimed |
| US-5654326-A | SEPTIC SHOCK; HUMAN NONPANCREATIC SECRETORY PHOSPHOLIPASE | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| US-5641800-A | ALLEVIATE EFFECT OF SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, AND RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY (US) | 1997-06-24 | — | — | US | claimed |
| EP-0339661-B1 | Photochromic substances | RODENSTOCK OPTIK G (DE) | 1994-04-20 | — | — | EP | claimed |
| CN-1073174-A | Hete rocyclic derivatives | ICI PLC (GB) | 1993-06-16 | — | — | CN | claimed |
| US-4959471-A | IMPROVED MIGRATION PROPERTIES IN PLASTICS, LENSES | OPTISCHE WERKE G. RODENSTOCK (DE) | 1990-09-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029948-A1 | Novel sPLA2 inhibitors | PLA2G12A, PLA2G4A, PLAAT2 | CALM1 3361/4885TAAR1 3498/4885LMNA 3724/4885 |
| US-20030191175-A1 | Indole sPLA2 inhibitors | PLAAT2, PLA2G4A, PLA2G12A | CALM1 3424/4885TAAR1 3580/4885LMNA 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.