Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | PTP4A3 | O75365 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NAT1 | P18440 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173297 | 1.00 | PIM1 (0.51) | PIM1TDP1PTP4A3MEN1KMT2A | |
| SCHEMBL14226362 | 0.86 | PIM1 (0.71) | PIM1PTP4A3MEN1KMT2ARAB9A | |
| SCHEMBL8187020 | 0.86 | TDP1 (0.60) | TDP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8187019 | 0.86 | TDP1 (0.60) | TDP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8173766 | 0.82 | PIM1 (0.74) | PIM1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL8173768 | 0.82 | PIM1 (0.74) | PIM1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL15101827 | 0.73 | TTR (0.69) | PIM1TDP1MEN1KMT2AMAPT | |
| SCHEMBL8171866 | 0.71 | PIM1 (0.46) | PIM1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL8171863 | 0.71 | PIM1 (0.46) | PIM1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL8177340 | 0.71 | GSK3B (0.58) | PIM1TDP1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |