Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200153 | 0.93 | DPP8 (0.35) | DPP8DPP9DPP7ABHD6DDB1 | |
| SCHEMBL4595406 | 0.93 | DPP8 (0.35) | DPP8DPP9DPP7ABHD6DDB1 | |
| SCHEMBL8060885 | 0.87 | XIAP (0.36) | DPP8DPP9DPP7ABHD6DDB1 | |
| SCHEMBL4596301 | 0.86 | — | — | |
| SCHEMBL8186412 | 0.86 | DPP8 (0.32) | DPP8DPP9DPP7 | |
| SCHEMBL4406308 | 0.84 | DPP4 (0.44) | DPP8DPP9DPP7ABHD6KCNH2 | |
| SCHEMBL4257147 | 0.84 | DPP4 (0.44) | DPP8DPP9DPP7ABHD6KCNH2 | |
| SCHEMBL8193153 | 0.80 | — | — | |
| SCHEMBL4589829 | 0.80 | — | — | |
| SCHEMBL4259244 | 0.79 | ELANE (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070358-A2 | N-CYCLOPROPYL-HYDROXYPROLINE-BASED TRIPEPTIDIC HEPATITIS C SERINE PROTEASE INHIBITORS CONTAINING AN ISOINDOLE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE OR PYRROLOPYRAZINE HETEROCYCLE IN THE SIDE CHAIN | PHENOMIX CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |