Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYCS | P99999 | 4/20 | 0.63 |
| ▸ | TOP1 | P11387 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | CD74 | P04233 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917438 | 0.92 | TOP1 (0.69) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL25395955 | 0.92 | TOP1 (0.68) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL30493187 | 0.92 | TOP1 (0.68) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL28499238 | 0.91 | CYCS (0.67) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL28500846 | 0.91 | CYCS (0.67) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL28479053 | 0.91 | CYCS (0.67) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL28498162 | 0.91 | CYCS (0.67) | CYCSTOP1KDM4ENPC1ALDH1A1 | |
| SCHEMBL31392584 | 0.85 | TOP1 (0.86) | CYCSTOP1ENPP2CSNK1DCSNK1E | |
| Porphirin SCHEMBL29373094 | 0.85 | TOP1 (0.86) | CYCSTOP1ENPP2CSNK1DCSNK1E | |
| Porphirin SCHEMBL8185370 | 0.85 | TOP1 (0.86) | CYCSTOP1ENPP2CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087493-A | ENZYME IHIBITORS | REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0988037-A1 | PORPHYRIN COMPOUNDS AS TELOMERASE INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998033503-A1 | PORPHYRIN COMPOUNDS AS TELOMERASE INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-08-06 | — | — | WO | disclosed |