Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.69 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16208771 | 0.86 | ALDH1A1 (0.74) | ALDH1A1KMT2AMEN1LMNAAPOBEC3A | |
| SCHEMBL28513685 | 0.80 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1LMNAAPOBEC3A | |
| SCHEMBL24209778 | 0.79 | NPSR1 (0.67) | ALDH1A1KMT2AMEN1LMNAAPOBEC3A | |
| SCHEMBL1702530 | 0.78 | CYP1A2 (0.92) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL24209697 | 0.78 | ALDH1A1 (0.82) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL24210088 | 0.76 | KMT2A (0.83) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL24209779 | 0.76 | KMT2A (0.76) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL24209749 | 0.76 | KMT2A (0.82) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL27804013 | 0.75 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6346019 | 0.75 | KMT2A (0.76) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |