Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247436 | 0.83 | MTOR (0.64) | MTORHPGDPIK3CAPIK3CGPIM1 | |
| SCHEMBL1247438 | 0.83 | MTOR (0.64) | MTORHPGDPIK3CAPIK3CGPIM1 | |
| SCHEMBL13846678 | 0.78 | PIM1 (0.67) | HPGDPIM1PIM3PIM2GSK3B | |
| SCHEMBL22409611 | 0.78 | PIM1 (0.67) | HPGDPIM1PIM3PIM2GSK3B | |
| SCHEMBL22423780 | 0.78 | PIM1 (0.67) | HPGDPIM1PIM3PIM2GSK3B | |
| SCHEMBL22409640 | 0.76 | CISD1 (0.49) | MTORHPGDPIK3CAPIK3CGPIM1 | |
| SCHEMBL22423741 | 0.76 | CISD1 (0.49) | MTORHPGDPIK3CAPIK3CGPIM1 | |
| SCHEMBL8172756 | 0.75 | PIM1 (0.57) | HPGDPIK3CGPIM1PIM3PIM2 | |
| SCHEMBL8187128 | 0.72 | PIM1 (0.53) | HPGDPIM1PIM3PIM2GSK3B | |
| SCHEMBL4089557 | 0.71 | PTP4A3 (0.60) | HPGDPIK3CGPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |