Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14590338 | 0.81 | HTT (0.47) | ALDH1A1MAPTHTTL3MBTL1NPSR1 | |
| SCHEMBL6036195 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2AMAPTHTT | |
| SCHEMBL8280454 | 0.80 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KMT2AMAPTHTT | |
| SCHEMBL5793592 | 0.79 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KMT2AMAPTHTT | |
| SCHEMBL28673574 | 0.78 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KMT2AMAPTHTT | |
| SCHEMBL2971730 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KMT2AHTTL3MBTL1CA12 | |
| SCHEMBL29656890 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KMT2AHTTL3MBTL1CA12 | |
| SCHEMBL8173414 | 0.76 | HTT (0.38) | ALDH1A1SMN1; SMN2MAPTHTTL3MBTL1 | |
| SCHEMBL5342999 | 0.75 | HTT (0.54) | ALDH1A1SMN1; SMN2MAPTHTTHPGD | |
| SCHEMBL23317645 | 0.75 | HTT (0.57) | ALDH1A1SMN1; SMN2MAPTHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043284-A | ACYL COENZYME A: CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS | GLAXO WELLCOME INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5776951-A | ANTICHOLESTEROL AGENT | GLAXO WELLCOME INC. (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0706508-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001326-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-12 | — | — | WO | disclosed |