Sugi Predict

Sugi Predict / Compounds / SCHEMBL5793592

SCHEMBL5793592

SCHEMBL5793592

O=C(O)Nc1c(F)cc(F)cc1Br

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.57
▸ SMN1; SMN2 Q16637 3/20 0.57
▸ KMT2A Q03164 4/20 0.57
▸ MAPT P10636 2/20 0.57
▸ HTT P42858 1/20 0.55
▸ MEN1 O00255 2/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ CA12 O43570 1/20 0.48
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ HPGD P15428 2/20 0.47
▸ HSD17B10 Q99714 2/20 0.47
▸ THRB P10828 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2092769 0.86 RAPGEF4 (0.42) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL6036195 0.83 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL21058805 0.81 IDH1 (0.47) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL4115494 0.81 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL28673574 0.80 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL8188784 0.79 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL5761616 0.79 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL6390219 0.78 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL15329540 0.75 GAA (0.55) ALDH1A1SMN1; SMN2KMT2AMAPTHTT
SCHEMBL11431492 0.75 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KMT2AMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2023-01-26 — — US disclosed
US-11358969-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-06-14 — — US disclosed
US-20200331917-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2020-10-22 — — US disclosed
US-10689388-B1 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2020-06-23 — — US disclosed
US-10647693-B2 Inhibitors of influenza virus replication, application methods and uses thereof NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (HK) 2020-05-12 — — US disclosed
EP-3612030-A2 INDOLE AHR INHIBITORS AND USES THEREOF Kyn Therapeutics (US) 2020-02-26 — — EP disclosed
US-10570138-B2 Indole AHR inhibitors and uses thereof KYN THERAPEUTICS (US) 2020-02-25 — — US disclosed
US-20190194159-A1 INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2019-06-27 — — US disclosed
US-20190185456-A1 INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2019-06-20 — — US disclosed
US-20180327411-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2018-11-15 — — US disclosed
WO-2018195397-A2 INDOLE AHR INHIBITORS AND USES THEREOF KYN THERAPEUTICS (US) 2018-10-25 — — WO disclosed
EP-1651637-A1 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES Wyeth (US) 2006-05-03 — — EP disclosed
US-20050032873-A1 3-Amino chroman and 2-amino tetralin derivatives WYETH (US) 2005-02-10 — — US disclosed
WO-2005012291-A1 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES WYETH (US) 2005-02-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180327411-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885
US-10647693-B2 Inhibitors of influenza virus replication, application methods and uses thereof EIF2AK2, POLRMT, SNRPE ALDH1A1 3538/4885SMN1; SMN2 4771/4885KMT2A 1653/4885
US-10570138-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885
US-20050032873-A1 3-Amino chroman and 2-amino tetralin derivatives TPH2, HTR2C, HTR7 ALDH1A1 3377/4885SMN1; SMN2 2258/4885KMT2A 1963/4885
US-11358969-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885
US-20200331917-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885
US-20190194159-A1 INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF EIF2AK2, POLRMT, SNRPE ALDH1A1 3538/4885SMN1; SMN2 4771/4885KMT2A 1653/4885
US-20190185456-A1 INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF POLRMT, EIF2AK2, POLM ALDH1A1 3790/4885SMN1; SMN2 4713/4885KMT2A 1637/4885
US-10689388-B1 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 ALDH1A1 316/4885SMN1; SMN2 4883/4885KMT2A 622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.