Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 18/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188956 | 0.91 | TLR8 (0.53) | TLR8TLR7CA12CA9KDM4E | |
| SCHEMBL7508446 | 0.85 | TLR8 (0.62) | TLR8TLR7 | |
| SCHEMBL12701620 | 0.85 | TLR8 (0.57) | TLR8TLR7 | |
| SCHEMBL3032882 | 0.84 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL10326201 | 0.84 | TLR8 (0.56) | TLR8TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL7505631 | 0.84 | TLR8 (0.63) | TLR8TLR7ALDH1A1 | |
| SCHEMBL8191084 | 0.83 | TLR8 (0.60) | TLR8TLR7 | |
| SCHEMBL22771214 | 0.83 | TLR8 (0.60) | TLR8TLR7 | |
| SCHEMBL8179986 | 0.83 | TLR8 (0.54) | TLR8TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL8196330 | 0.83 | TLR8 (0.70) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043238-A | 2-Aminobenzazapine derivatives | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0825186-A1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER INC. (US) | 1998-02-25 | — | — | EP | disclosed |