SCHEMBL8189665

SCHEMBL8189665

Cc1ccc(/N=N\N)c(C)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.57
RAB9A P51151 5/20 0.57
ALDH1A1 P00352 9/20 0.49
MAPT P10636 6/20 0.49
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
ATM Q13315 3/20 0.49
KDM4E B2RXH2 3/20 0.49
CYP3A4 P08684 2/20 0.49
POLB P06746 2/20 0.49
CYP1A2 P05177 1/20 0.49
LMNA P02545 5/20 0.47
ADRA2A P08913 1/20 0.47
THRB P10828 2/20 0.42
GAA P10253 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 3/20 0.39
TP53 P04637 1/20 0.39
L3MBTL1 Q9Y468 4/20 0.39
HTT P42858 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11693234 0.85 NPC1 (0.72) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL11693231 0.85 NPC1 (0.72) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL11020065 0.82 TDP1 (0.44) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL11022109 0.82 TDP1 (0.44) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL18084260 0.80 ALDH1A1 (0.56) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL22755750 0.79 NPC1 (0.59) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL14926696 0.77 NPC1 (0.62) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL13312943 0.76 MAPT (0.60) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL14926679 0.76 MAPT (0.60) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL18590721 0.76 MAPT (0.60) NPC1RAB9AALDH1A1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991795-A1 ELECTRO-CHEMICAL DEPOSITION SYSTEM AND METHOD OF ELECTROPLATING ON SUBSTRATES Applied Materials, Inc. (US) 2000-04-12 EP disclosed
WO-1999054527-A2 ELECTRO-CHEMICAL DEPOSITION SYSTEM AND METHOD OF ELECTROPLATING ON SUBSTRATES APPLIED MATERIALS, INC. (US) 1999-10-28 WO disclosed
US-5760042-A INHIBITOR OF PHOSPHODIESTERASES SANKYO COMPANY, LIMITED (JP) 1998-06-02 US disclosed
US-5616600-A Griseolic acid compounds and their use as a phosphodiesterase inhibitor SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
US-5556975-A CYCLIC GMP PHOSPHODIESTERASE INHIBITOR SANKYO COMPANY, LIMITED (JP) 1996-09-17 US disclosed
US-5532369-A NUCLEOTIDE INHIBITORS OF PHOSPHODIESTERASE SANKYO COMPANY, LIMITED (JP) 1996-07-02 US disclosed
US-5498819-A INHIBITORS OF PHOSPHODIESTERASE AS NEUROTROPIC AGENTS, ANTIINFLAMMATORY AGENTS, MUSCLE RELAXANTS, ANTICARCINOGENIC AGENTS AND ANTIDIABETIC AGENTS SANKYO COMPANY, LIMITED (JP) 1996-03-12 US disclosed
US-4783532-A Process for preparing griseolic acid derivatives SANKYO COMPANY LIMITED (JP) 1988-11-08 US disclosed
EP-0200522-A2 Process for preparing griseolic acid derivatives SANKYO COMPANY LIMITED (JP) 1986-11-05 EP disclosed