Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 7/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879287 | 0.69 | TSHR (0.47) | KMT2AMEN1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL7639037 | 0.69 | MEN1 (0.39) | KMT2AMEN1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL5207266 | 0.69 | GSK3B (0.46) | POLBGPR35TDP1L3MBTL1GSK3B | |
| SCHEMBL2497335 | 0.68 | POLB (0.39) | KMT2AMEN1POLBTDP1 | |
| SCHEMBL2493216 | 0.68 | POLB (0.44) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL2494264 | 0.66 | POLB (0.41) | KMT2AMEN1POLB | |
| SCHEMBL3836429 | 0.66 | POLB (0.55) | KMT2APOLBGPR35TDP1L3MBTL1 | |
| SCHEMBL2808786 | 0.64 | GSK3B (0.50) | KMT2AMEN1POLBGPR35TDP1 | |
| Hydrochloric Acid SCHEMBL7810688 | 0.64 | POLB (0.53) | KMT2APOLBGPR35TDP1L3MBTL1 | |
| SCHEMBL27363412 | 0.64 | GPR35 (0.46) | KMT2APOLBGPR35TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970036-A1 | ARYL- AND HETEROARYLCYCLOHEXENYL SUBSTITUTED ALKENES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998039284-A1 | ARYL- AND HETEROARYLCYCLOHEXENYL SUBSTITUTED ALKENES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1998-09-11 | — | — | WO | disclosed |