Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9863059 | 0.93 | LMNA (0.62) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8194578 | 0.92 | LMNA (0.61) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8197126 | 0.90 | LMNA (0.59) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8191379 | 0.90 | LMNA (0.59) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL30724415 | 0.89 | LMNA (0.58) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8191101 | 0.89 | LMNA (0.58) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL7811023 | 0.87 | GLA (0.57) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8194530 | 0.87 | LMNA (0.56) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL27461074 | 0.86 | LMNA (0.55) | LMNAMAPTKDM4EGLAALDH1A1 | |
| SCHEMBL8196433 | 0.84 | LMNA (0.72) | LMNAMAPTKDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |