Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802433 | 0.90 | LMNA (0.61) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL3841711 | 0.88 | LMNA (0.55) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL3597798 | 0.86 | MAPT (0.74) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL8607862 | 0.85 | LMNA (0.72) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL8190013 | 0.84 | LMNA (0.64) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL9704241 | 0.84 | MAPT (0.57) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL10582031 | 0.84 | LMNA (0.70) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL3359357 | 0.84 | LMNA (0.70) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL10582049 | 0.84 | LMNA (0.70) | LMNAMAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL9863059 | 0.83 | LMNA (0.62) | LMNAMAPTKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067387-C | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 2001-06-20 | — | — | CN | disclosed |
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| CN-1168670-A | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1997-12-24 | — | — | CN | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |
| US-5246933-A | Applying and killing | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-09-21 | — | — | US | disclosed |
| WO-1993004049-A1 | NEMATOCIDAL QUINOXALINE DERIVATIVES | ZENECA LIMITED (GB) | 1993-03-04 | — | — | WO | disclosed |