Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28241436 | 0.83 | KDM4E (0.55) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL17744722 | 0.80 | MEN1 (0.40) | KDM4EALDH1A1HPGDGLAMAPT | |
| SCHEMBL476972 | 0.76 | KDM4E (0.52) | KDM4EGAAALDH1A1HPGDCACNA2D1 | |
| SCHEMBL28232527 | 0.76 | KDM4E (0.52) | KDM4EGAAALDH1A1HPGDCACNA2D1 | |
| SCHEMBL28318282 | 0.75 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL17423155 | 0.75 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL476955 | 0.75 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL28231497 | 0.75 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL6266749 | 0.75 | KDM4E (0.53) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL12386870 | 0.72 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6033909-A | INHIBITORS OF GENE EXPRESSION | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-03-07 | — | — | US | disclosed |
| EP-0552766-A2 | Oligonucleotide analogues, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-28 | — | — | EP | disclosed |